This could be either a missing policy that blocks the traffic on the default block policy or a routing issue between zone 54 and this host.
Does a trace route go part of the way and indicate where the problem occurs?
Does the ping create a session?
Run this during the ping on the firewall to see if a session is generated. If not, you are missing a policy to permit the traffic.
show security flow session source-prefix 192.168.54.0/24 destination-prefix 10.0.2.250